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KMID : 0616120180490030240
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Korean Journal of Pharmacognosy
2018 Volume.49 No. 3 p.240 ~ p.245
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Anti-hypertensive Effects of DHP1501, Ethanolic Extracts from Eleutherococcus sessiliflorus Fruits, via Inhibition of Angiotensin Converting Enzyme and Activation of Endothelial Nitric Oxide Synthase
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Kim Ha-Neul
Kim Hye-Min
Jang Jun-Hee
Yoon Koung-Eun
Lee Yeong-Geun
Baek Nam-In
Lee Dae-Young
Jung In-Ho
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Abstract
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The fruits of Eleutherococcus sessiliflorus (Rupr. & Maxim.) S. Y. Hu (Araliaceae), as edible fruits, were traditionally used for ingredients of wine or tea in Eastern Asia. In addition to, the fruits of E. sessiliflorus were known for having antioxidant and anti-inflammatory effects. Recently, we investigated that the ethanolic extracts of E. sessiliflorus fruits (DHP1501) have effects on hypertension via vasorelaxation and decrease of blood pressure. In the present study, we investigated that the gene and protein expression levels of endothelial nitric oxide synthase (eNOS) was increased by treatment of DHP1501 in HUVECs. Moreover, we confirmed the angiotensin converting enzyme inhibitory activity of DHP1501 through in vitro tasks. Therefore, DHP1501 could be a candidate of functional food for alleviating hypertension.
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KEYWORD
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Eleutherococcus sessiliflorus fruits, Hypertension, Endothelial nitric oxide synthase, Angiotensin converting enzyme
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